Matrix metalloproteinase-9 gene polymorphism (-1562 C/T) and its correlation with diabetic nephropathy

Abstract Background Matrix metalloproteinase 9 (MMP-9) is an important inflammatory marker in diabetic nephropathy. Many studies assessed the association between MMP-9 gene polymorphism and different microvascular complications of type 2 diabetes mellitus, though results were inconclusive need further exploration. Our study aimed to assess -1562C/T nephropathy patients with mellitus. Results Taking CC genotype rs3918242 (MMP-9-1562C/T SNP) as reference C allele, TT genotype, T allele showed significantly lower frequency group than without (2.9% versus 20%, 20% 35.7% respectively), possible significant protective effect against development (OR = 0.269, 0.450 respectively); it was considered independent predictor for occurrence. Conclusions This suggested that single nucleotide had a role also early prediction susceptible this complication, so helps prevention management those patients.